| (b) Introduction to Molecular Methods in Functional Genomics |
This course will focus on recent methodological advances in molecular genetics. Topics will include current genotyping strategies, epigenetics, micro RNA, gene expression profiling and model systems. In addition, there will be comprehensive practical training in the core molecular genetics techniques of DNA extraction, sample management, quantification, amplification by polymerase chain reaction (PCR), genotyping and DNA methylation. The course is aimed at those new to molecular methods in functional genomics.
Specific components of the course will include:
An introduction to association studies and statistics
Methods of genotyping - from markers to microarrays
Epigenetic methods
Linkage disequilibrium
Gene expression profiling
Copy number variation
Micro RNA
In vivo and in vitro model systems
Using bioinformatic tools
Scientific Directors: Cathy Fernandes & Jon Mill
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COURSE FEE: £700 (external) £500 (internal)
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This course will teach the basic principles of the classical twin model as well as the basic skills to analyze twin data by teaching delegates how to write simple scripts and how to interpret the output. This year we will introduce OpenMx, a free open source software, which works as an integral part of the R statistical software system. OpenMx offers all the features you would expect in a SEM software package (as the old Mx), but works in ways that will make your modeling jobs easier and will allow the full power of the R statistical software system for data manipulation, graphics, simulation, and report generation. For more information on all the features go to: http://openmx.psyc.virginia.edu/openmx-features.
The content of the course is aimed primarily at researchers who are actually planning to conduct genetic analyses on twin data and will include a fair amount of program specific features. The course is also aimed at old Mx users, whishing to switch to the new program, since all the scripting will be based on OpenMx. Knowledge of R or old Mx is not necessary. The Lectures and practicals will cover (i) intro to R and OpenMx (ii) univariate and multivariate models applied to continuous raw data; (iii) univariate models applied to ordinal data (liability threshold models fitted to contingency tables); (iv) sex-limitation models. In addition, we will address some basic concepts of structural equation modeling like matrix algebra, path tracing, maximum likelihood estimation and power issues.
Scientific Directors: Fruhling Rijsdijk, Irene Rebollo-Mesa & Ben Neale
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COURSE FEE: £500 (external) £300 (internal)
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| Please note: Internal applicants are those working or studying within King's College London and external applicants are all those who are not part of King's College London. |
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The week will consist of a series of general sessions, and a series of lectures and practical sessions which
are specific to the chosen course: General sessions (common to all courses) These morning sessions
are intended to give conceptual overviews of genetic approaches to complex behavioural phenotypes and to
provide discussions of recent advances and ways forward in the field.
You are warmly invited to various social events during the week. Dates and events as follows:-
 Monday 12th - Pub night
Wednesday 14th - Cocktail party at the SGDP Centre (5-11pm)
Friday 16th - Drinks reception (5-7pm)
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Post-graduate students, post-doctoral researchers, and clinical researchers who wish to learn more about or move
into the field.
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Applications are accepted from 1st December 2009.
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To apply in writing, please send a short CV and covering letter outlining your reasons for applying to:
Summer School 2010,
MRC, SGDP, P080
Insitute of Psychiatry,
De Crespigny Park,
Denmark Hill,
London SE5 8AF
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